Abstract
Short bowel syndrome results in significant morbidity and mortality. Tissue-Engineered Small Intestine (TESI) may serve as a viable replacement. TESI has previously been generated from donor cells implanted immediately, but this technique may prove impossible in children who are critically ill, hemodynamically unstable, or septic. We have previously generated TESI from frozen murine organoid units (OU), multicellular clusters containing epithelium and mesenchyme, but with low success rates. We hypothesized that advanced cryopreservation techniques could improve viability of murine OU and be applied to human OU for future therapies.
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