Abstract
The effects of vitrectomy and replacement with hyaluronic acid or saline on vitreous scar tissue formation were examined in rabbits. A scar tissue bridge was grown across the vitreous cavity along a transcleral suture. In one group of eyes, the bridge was grown across normal vitreous and non-banded collagen of 15 nm diameter was laid down. In second group in which vitrectomy was done 2–8 months previously, the fluid cavity was replaced with saline. In these eyes, striated collagen of 30–60 nm diameter was deposited. In a third group after vitrectomy and replacement with purified hyaluronic acid, a mixture of fine and thicker fibrils was seen. In both the latter two groups patches of enormous collagen fibrils of up to 350 nm diameter (tactoids) were found. No differences in the proliferating cell lines were found in any of the three groups. It is suggested that normal vitreous and its glycosaminoglycan component (hyaluronic acid) may influence the extracellular macromolecular organization of vitreous collagen.
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