Abstract
Background: Vitiligo is an acquired cutaneous disorder characterised by depigmented patches on the skin and mucous membranes, due to the loss of functioning melanocytes. Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis. Although several theories have been proposed about the pathogenesis of vitiligo, the precise cause remains unknown. Theories regarding destruction of melanocytes include autoimmune mechanisms, cytotoxic mechanisms, an intrinsic defect of melanocytes, oxidant-antioxidant mechanisms, and neural mechanisms. Autoimmune hypothesis is based on the clinical association of vitiligo with certain diseases known as autoimmune. The autoimmune theory proposes alteration in humoral and cellular immunity in the destruction of melanocytes.This article presents you a recent overview of autoimmune basis of vitiligo.
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