Abstract
Recently, the rapid and extensive spread of a novel human RNA betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency, originated in Wuhan, China. The disease caused by this new coronavirus, called "COVID-19", is very contagious. Although most of infected subjects are asymptomatic or present with mild flu-like symptoms, the rapid spread of the virus has resulted in a significant amount of serious interstitial pneumonia that may quickly develop into severe acute respiratory distress syndrome (ARDS), septic shock, sepsis-induced coagulopathy and fatal multiorgan dysfunction. Hence, the unabated spread of the disease demands an immediate need to explore all the plausible therapeutic and prophylactic strategies for reducing the high morbidity and mortality of this infection. At present, there is no vaccine or certainly effective antiviral treatment for human SARS-Cov-2 and the mainstay of clinical management is prevalently symptomatic treatment combined with a panel of drugs having variable and uncertain efficacy. Unfortunately, no many drugs have yet been approved to treat human SARS-Cov-2 infection and many agents are administered in off label route; several options are being studied to control or prevent clinical manifestations of this infection, including monoclonal antibodies, antiviral and anti-cytokine agents, antibiotics, and other drugs. Given that several vitamins are known to have antimicrobial properties and immunomodulatory activity, a potential role of vitamins in the COVID-19 treatment was investigated.
Highlights
In these months, the diffusion of a novel human RNA betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency, originated in Wuhan, China
Most of infected subjects by SARS-Cov-2 are asymptomatic or present with mild flu-like symptoms, such as fever, cough, arthromyalgias and fatigue [2], and diarrhea, ageusia and anosmia [3,4], the rapid spread of the virus has resulted in a significant amount of serious interstitial pneumonia that may quickly develop into severe acute respiratory distress syndrome (ARDS), septic shock and fatal multiorgan dysfunction that are the most severe clinical manifestations of SARS-Cov-2 infection
SARS-CoV-2 infection is causing a worldwide public health emergency and several options are being studied to control and prevent clinical manifestations of this infection; many studies and clinical trials have been started and are currently ongoing in all Countries involved in this severe pandemic
Summary
The diffusion of a novel human RNA betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency, originated in Wuhan, China. Despite some vitamins are known to have antimicrobial properties and immunomodulatory activity, at the moment poor relevance regarding a potential role of vitamins supplementation in the therapeutic armamentarium against SarsCov-2 we have found. In this narrative review any benefits from vitamins in the COVID-19 treatment was investigated
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