Abstract
Background. Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression. Data on the actual vitamin status of patients are necessary to develop measures for its improvement. Aim. To characterize the supply of persons with non-communicable diseases with vitamins A, E, C, B2 and -carotene by determining their level in the blood of patients. Material and methods. The blood serum level of vitamins C, A, E, B2 and -carotene in 138 patients (41 men and 97 women) 2280 years old with cardiovascular diseases, obesity, gastrointestinal diseases, type 2 diabetes mellitus (T2DM), osteoarthrosis has been determined. Results. Vitamin C concentration corresponded to adequate status in approximately 2/3 of the examined patients; among patients with T2DM, such sufficiency occurred 1.61.9 fold less often than in other groups. The frequency of reduced levels of vitamins C, A and E was statistically significantly more frequent in patients with gastrointestinal diseases. The -/-tocopherol ratio in the serum of patients in all groups was close to 1:50, while in patients with gastrointestinal diseases reached 1:60.7. The proportion of patients sufficiently supplied with all studied vitamins ranged from 15.8 to 70.0%. Patients with osteoarthrosis were best of all provided with all vitamins: multiple (3 or more vitamins) vitamin deficiency was not found. In other groups of patients, multiple vitamin deficiency occurred in 5.327.6% of the examined (an average of 16.4%). Among patients with gastrointestinal diseases there was not a single person sufficiently provided with all the studied vitamins. Multiple vitamin deficiency in patients with gastrointestinal diseases was detected more often (p 0.01) compared with patients with T2DM and osteoarthrosis. Given the high prevalence of vitamin D deficiency, it is possible to extrapolate that a significant proportion of patients with a combined deficiency of 2 vitamins (6.931.6% in the samples examined) will move into the category of persons with a simultaneous deficiency of 3 vitamins. Conclusion. The purposeful development of supplements containing effective doses of vitamins for various nosologies is necessary.
Highlights
Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression
Vitamin C concentration corresponded to adequate status in approximately 2/3 of the examined patients; among patients with type 2 diabetes mellitus (T2DM), such sufficiency occurred 1.6–1.9 fold less often than in other groups
The proportion of patients sufficiently supplied with all studied vitamins ranged from 15.8 to 70.0%
Summary
Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression. Among patients with gastrointestinal diseases there was not a single person sufficiently provided with all the studied vitamins. Обоснование Дефицит отдельных витаминов является фактором риска развития и прогрессирования ряда алиментарно-зависимых заболеваний. Превышающий 35 кг/м2, является фактором риска недостаточности витамина В1 [2]. Ухудшающим обеспеченность организма витаминами, является прием лекарственных средств, большинство из которых нарушают их адсорбцию и/или метаболизм [4,5,6]. Представляется целесообразным актуализировать данные по обеспеченности витаминами пациентов с различными заболеваниями, что необходимо для разработки мер по улучшению витаминного статуса. Цель исследования — охарактеризовать обеспеченность витаминами А, Е, С, В2 и β-каротином по их содержанию в крови у пациентов с алиментарно-зависимыми заболеваниями, поступивших на лечение в клинику лечебного питания.
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