Vitamin K-dependent coagulation factor deficiency due to cefminox sodium

Abstract

A 55-year-old female patient with cholecystitis, gallstone and secondary acute pancreatitis received an IV infusion of cefminox sodium 2.0 g twice daily. Eight days later, she developed large area of ecchymosis on her skin below the waist and abdomen, especially on that of the lower limbs. Laboratory tests showed the prothrombin time (PT) 63.0 s, prothrombin activity (PTA) 0.12, international normalized ratio (INR) 5.21, coagulation factor II activity 0.32, coagulation factor VII activity 0.02, and coagulation factor X activity 0.27. Vitamin K-dependent coagulation factor deficiency due to cefminox sodium was considered. Cefminox sodium was stopped immediately and an intramuscular injection of mephyton 10 mg once daily was given. Three days later, the laboratory tests showed PT 11.0 s, PTA 1.12, INR 0.94, coagulation factor II activity 0.83, coagulation factor VII activity 0.73, and coagulation factor X activity 0.84. Key words: Cephamycins; Vitamin K-dependent coagulation factor deficiency