Abstract
Vitamin K is best known for its role in blood coagulation. The reduced form of vitamin K is a necessary cofactor for the γ-carboxylase enzyme that converts specific glutamic acid...
Highlights
The vitamin K-dependent coagulation proteins are produced primarily in the liver and function within the systemic circulation and vasculature
These studies suggest that vitamin K-dependent proteins have a role in maintaining healthy joints
The Ballal[26] study examined indication bias by including only patients prescribed anticoagulants for atrial fibrillation and by comparing those prescribed warfarin with patients matched for age and sex prescribed a direct oral anticoagulants (DOACs)
Summary
The vitamin K-dependent coagulation proteins are produced primarily in the liver and function within the systemic circulation and vasculature. Mice aged on a low vitamin K diet were noted to have greater articular cartilage proteoglycan loss than mice aged on a control diet.[17] Together, these studies suggest that vitamin K-dependent proteins have a role in maintaining healthy joints (figure 1).
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