Abstract
Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity and mortality closely related to cardiovascular disease, malignancies, and cirrhosis. It is believed that oxidative stress is a main player in the development and progression of NAFLD. Currently, a pharmacological approach has become necessary in NAFLD because of a failure to modify lifestyle and dietary habits in most patients. Vitamin E is a potent antioxidant that has been shown to reduce oxidative stress in NAFLD. This review summarizes the biological activities of vitamin E, with a primary focus on its therapeutic efficacy in NAFLD.
Highlights
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of excessive fat in the liver, as demonstrated by imaging or by histology, in the setting of no significant alcohol consumptionand the absence of any secondary cause [1].NAFLD encompasses a broad pathological spectrum of phenotypes ranging from isolated hepatic steatosis (IHS) to nonalcoholic steatohepatitis (NASH)—the progressive form of fatty liver disease associated with inflammation and cellular injury, which can lead to NASH-related cirrhosis and hepatocellular carcinoma [2]
This review summarizes the biological activities of vitamin E, with a primary focus on its therapeutic efficacy in NAFLD
No definite pharmacological treatment has been approved for NAFLD, and patients are often advised to engage in physical activity and lose weight, which is difficult to achieve and more difficult to maintain
Summary
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of excessive fat in the liver, as demonstrated by imaging or by histology, in the setting of no significant alcohol consumptionand the absence of any secondary cause [1]. NAFLD encompasses a broad pathological spectrum of phenotypes ranging from isolated hepatic steatosis (IHS) to nonalcoholic steatohepatitis (NASH)—the progressive form of fatty liver disease associated with inflammation and cellular injury, which can lead to NASH-related cirrhosis and hepatocellular carcinoma [2]. This pathology is regarded as a leading cause of chronic liver diseases and liver transplantation in most countries [3]. The present review briefly discusses the biological activities of vitamin E, focusing on its as a treatment forasNAFLD/NASH To this aim, weaim, thetherole oxidative stress in the potential a treatment for NAFLD/NASH.
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