Abstract
The present study aims to examine the effects of a palm-oil-derived vitamin Emixture containing tocotrienol (˜70%) and tocopherol (˜30%) on plasma lipids andon the formation of atherosclerotic plaques in rabbits given a 2% cholesterol diet.Eighteen New Zealand White rabbits (2.2–2.8 kg) were divided into three groups;group 1 (control) was fed a normal diet, group 2 (AT) was fed a 2% cholesterol dietand group 3 (PV) was fed a 2% cholesterol diet with oral palm vitamin E (60mg/kgbody weight) given daily for 10 weeks. There were no differences in the totalcholesterol and triacylglycerol levels between the AT and PV groups. The PV grouphad a significantly higher concentrations of HDL-c and a lower TC/HDL-c ratiocompared to the AT group (P < 0.003). The aortic tissue content of cholesterol andatherosclerotic lesions were comparable in both the AT and PV groups. However,the PV group had a lower content of plasma and aortic tissue malondialdehyde (P< 0.005). Our findings suggest that despite a highly atherogenic diet, palm vitaminE improved some important plasma lipid parameters, reduced lipid peroxidation butdid not have an effect on the atherosclerotic plaque formation.
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More From: International Journal of Food Sciences and Nutrition
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