Abstract
Background: We studied the effects of vitamin D3 supplementation on serum levels of 25-hydroxyvitamin D and typical clinical symptoms in children with autism spectrum disorder (ASD). Methods: We enrolled 5 male and 1femaleJapanesechildren with ASD aged 3years. Serum25-hydroxy vitamin D was measured prior to after 9months of supplementation with oral vitamin D3 oil (2μg /day of vitamin D3, corresponding to twice the daily requirement). The Childhood Autism Rating Scale (CARS), Short Sensory Profile (SSP), Vineland-II were used to assess the severity of autism-related traits. Data were analyzed using a Wilcoxon test. Results: The 25-hydroxy vitamin D level were=20 ng/mL and Conclusion: These findings show that vitamin D supplementation might ameliorate typical clinical symptoms in children with autism spectrum disorder.
Highlights
MethodsWe enrolled 5 male and 1femaleJapanesechildren with Autism spectrum disorders (ASD) aged 3years
Autism spectrum disorders (ASD) are developmental disorders associated with a high individual and social burden, but their aetiology is poorly understood
Among the children in this study, vitamin D administration showed a positive effect on the “communication skills”, “ADL skills”, “social skills” or “motor skills” of two of the ASD children assessed with the Vineland-II
Summary
We enrolled 5 male and 1femaleJapanesechildren with ASD aged 3years. Serum25-hydroxy vitamin D was measured prior to after 9months of supplementation with oral vitamin D3 oil (2μg /day of vitamin D3, corresponding to twice the daily requirement). The Childhood Autism Rating Scale (CARS), Short Sensory Profile (SSP), Vineland-II were used to assess the severity of autism-related traits. Data were analyzed using a Wilcoxon test
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