Abstract
Objectives: 1.To estimate the level of serum 25 hydroxyvitamin D [25(OH)D] levels in patients of Acute respiratory tract infections (ARTI) admitted in the pediatric ward of a rural hospital. 2. To study the association between vitamin D deficiency and respiratory tract infections by estimating serum 25 hydroxyvitamin D [25(OH)D] levels in these patients. Materials and Methods: A hospital-based observational study was carried out in the patients admitted for ARTI from pediatric ward over 6 month’s duration. A total of 52 subjects between the age group 2 to 60 months were selected for the study. Results: Average Vitamin D levels were 39.6 ng/dl. On the basis of results of Vitamin D level it has been divided into four categories namely, deficient, insufficient, sufficient, and toxic. The number of children with deficient levels and insufficient levels were 33 (63%), sufficient levels were 11 (21 %), where as those with toxic levels were 8 (15%). Conclusion: Vitamin D levels are found to be lower in 63% cases of ARTI. However 15% children had Vitamin D levels in a toxic range. Therefore Vitamin D should not be arbitrarily administered in a therapeutic dose in all children with ARTI. Vitamin D supplementation is to be given after estimation of Vitamin D levels in all ARTI patients. There is a need of more studies to be done on a larger sample size to reach to a certain conclusion.
Highlights
Respiratory tract infections (RTIs) are common worldwide and are responsible for significant morbidity and mortality
Materials and Methods: A hospital-based observational study was carried out in the patients admitted for Acute respiratory tract infections (ARTI) from pediatric ward over 6 month’s duration
Vitamin D levels are found to be lower in 63% cases of ARTI
Summary
Respiratory tract infections (RTIs) are common worldwide and are responsible for significant morbidity and mortality. Acute respiratory tract Infections are major cause of morbidity and mortality in children below five years of age. Among the vitamin's main functions, it helps the body to absorb calcium, along with phosphorus from intestine. It helps to build bones and keep them strong and healthy. Regulation of intestinal calcium transport is still the Manuscript received: 8th October 2016 Reviewed: 20th October 2016 Author Corrected; 10th November 2016 Accepted for Publication: 30th November 2016 most significant effect of 1,25D acting through its binding to the VDR. It has become clear that vitamin D has pleiotropic effects, including some VDR transcription-independent actions and plays a key role in immune system regulation. Tissue and cell specific differences in the regulation of 25D are highly relevant to the roles of 25D and1,25D as immunemodulators
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