Vitamin D Supplementation as Add-on Therapy in Multiple Sclerosis-Balance between Benefit and Risk?: A Commentary on Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough.

Hans-Klaus Goischke

doi:10.3390/ijms20061513

Abstract

The excellent publication by Häusler and Weber [...].

Highlights

Vitamin D Supplementation as Add-on Therapy in Multiple Sclerosis—Balance between Benefit and Risk?: A Commentary on Vitamin D Supplementation in Central Nervous System Demyelinating Disease—Enough Is Enough
Because vitamin D (VD) intoxication without hypervitaminosis has been verified in anecdotal reports, calcium excretion can be determined by a 24 h urine collection as an option for confirmation [6]
At a weekly dose of 20,000 IU VD in people with multiple sclerosis (PwMS) and disease-modifying drugs (DMD), Holmoy et al did not achieve an overall effect on sNFL levels, but in a subgroup of patients not receiving DMD, sNFL decreased more than 30% [19]

Summary

Introduction

Vitamin D Supplementation as Add-on Therapy in Multiple Sclerosis—Balance between Benefit and Risk?: A Commentary on Vitamin D Supplementation in Central Nervous System Demyelinating Disease—Enough Is Enough. A moderate add-on therapy with vitamin D (VD) doses of up to 10,000 IU/day hardly presents a risk of hypercalcemia [3]. It is known that VD increases the absorption of calcium from the intestines, this effect is generally subject to physiological regulation.

Results

Conclusion