Abstract
Objective Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Methods Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444. Results Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Vitamin D supplementation group also showed a significantly elevated level of QUICKI. No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml). Conclusion The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.
Highlights
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting 6–10% of reproductive age women [1]. e main clinical manifestations of PCOS are irregular menstruation, polycystic ovarian morphology, hyperandrogenism, and infertility [2]
Exclusion criteria were as follows: (1) studies examining the effects of vitamin D combination with other interventions such as metformin, calcium, oral contraceptive, and so on; (2) studies examining the effects of vitamin D among patients with PCOS undergoing intrauterine insemination (IUI) or in vitro fertilization (IVF) treatment; (3) incomplete data; (4) genetic research
J.), and the following information was extracted: the last name of the first author, publishing year, country, criteria used for diagnosis of PCOS, study population, sample size, type and duration of intervention, dose of vitamin D intake, serum vitamin D level, biochemical indices of glucose and lipid metabolism including fasting plasma glucose (FPG), fasting insulin, HOMA-IR, QUICKI, serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), hypersensitive C-reactive protein, total testosterone (Total T), sex hormonebinding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS)
Summary
Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. E effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin D < 20 ng/ml). E findings of the present metaanalysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status Conclusion. e findings of the present metaanalysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status
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