Abstract
Pulmonary tuberculosis is the major cause of morbidity and mortality in the developing world. In South Asia, 80% of the apparently healthy population have vitamin D deficiency (<20 ng/mL). An association between vitamin D levels with tuberculosis has been described in several studies. But there are scarcities of studies carried out in Bangladesh to determine the association. This study, a case-control study with 2 years duration, determined and compared vitamin D concentration between pulmonary tuberculosis patients and healthy controls. Patients were recruited from the department of internal medicine, Bangabandhu Sheikh Mujib Medical University. All newly diagnosed patients of pulmonary tuberculosis who fulfiled the inclusion and exclusion criteria were selected as case; equal number of healthy subjects without pulmonary TB as control. Vitamin D level less than 20 ng/ml was considered deficiency; 21 to 29ng/ml as relative insufficiency and >30ng/ml as normal. Thirty partici- pants in each group were enrolled, from whom serum vitamin D concentration was measured, analyzed and interpreted. Mean serum vitamin D level was significantly low in case group than control group (p <0.05). The odds ratio corresponding to vitamin D deficiency in case group compared to control was 5.21 [95% CI (1.12 –27.53), (p= 0.015)]. Result indicates patients having vitamin D level <20 ng/ml has 5.21 times more risk to develop pulmonary tuberculo- sis. In conclusion, Vitamin D deficiency was significantly low in pulmonary tuberculo- sis patients and supplementation is required for them. BSMMU J 2021; 14(3): 85-91
Highlights
Cite this arƟcle: JSah S, Biswas SK, Biswas T, ChakraborƩy R, Sarker SS, Hasan MN, Abdullah ABM
Pulmonary tuberculosis is the major cause of morbidity and mortality which is prevalent in the developing world
Despite high burden of tuberculosis, scarcity of study was found in Bangladesh to determine association of vitamin D deficiency and tuberculosis
Summary
Cite this arƟcle: JSah S, Biswas SK, Biswas T, ChakraborƩy R, Sarker SS, Hasan MN, Abdullah ABM. BSMMU J 2021; 14(3): 85-91 of vitamin D in patient with tuberculosis as compared to controls and was more pronounced in females, individuals with low BMI, extra pulmonary and MDR tuberculosis.[8] Several recent studies in different population have associated vitamin D deficiency with increased risk of tuberculosis.[5] Talat et al from Karachi, assessed vitamin D levels in a cohort of tuberculosis patients and their contacts in Pakistan where most (79%) persons showed deficiency.[9] Low vitamin D levels were associated with a 5-fold increased risk for progression to tuberculosis These data were backed up by studies of Davies et al in the UK , as well as Thai, Chinese, Indian and Indonesian cohorts.[10] Despite high burden of tuberculosis, scarcity of study was found in Bangladesh to determine association of vitamin D deficiency and tuberculosis. Because of the high prevalence of pulmonary tuberculosis in South Asia in Bangladesh, it is important to compare the status of serum vitamin D level in pulmonary tuberculosis patients with that of healthy peoples
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