Vitamin D Status in Pediatric Patients with Dilated Cardiomyopathy

Abstract

Child heart failure is frequently brought on by dilated cardiomyopathy and it is characterized by impaired contraction and left ventricular or biventricular dilation. Evidence from recent years has demonstrated that vitamin D is crucial in a number of cardiovascular illnesses that are now more well recognized. This study evaluated vitamin D status in pediatric patients with dilated cardiomyopathy and compared it with that of healthy controls. This study is an observational case-control study, which included 23 patients with dilated cardiomyopathy aged less than 21 years of both genders, and a control group that included 45 healthy people who were matched for age, sex, and body mass index at the surgical specialty hospital-cardiac center in Erbil, Iraq. From each one, a blood sample was taken to evaluate the serum level of 25-hydroxyvitamin D3, parathyroid hormone, phosphorus, calcium, troponin I and creatin kinase-MB levels. The study revealed that the mean serum vitamin D3 level and mean serum calcium were significantly lower in dilated cardiomyopathy patients than controls, and significantly higher mean serum PTH and serum creatin kinase-MB in patients than controls. The difference in serum troponin I levels was not significant between the two groups. Furthermore, the study's outcomes revealed a substantial, moderately significant negative correlation between hypovitaminosis D and the dimensions of the left ventricle's end diastole and end systole in children with dilated cardiomyopathy