Vitamin d status in follicular fluid of young women with diminished ovarian reserve and the role in regulating anti-mullerian hormone expression

Abstract

Vitamin D deficiency is common among reproductive-aged women and the seasonal change in anti-mullerian hormone (AMH) levels correlates with the magnitude of change in vitamin D levels. But little is known about the vitamin D status in young patients with diminished ovarian reserve (DOR) and how vitamin D affects AMH. This study aims to evaluate the 25-hydroxyvitamin D (25-OHD) and AMH levels in young women with DOR and to study the effect of 1α,25-dihydroxyvitamin D [1α,25(OH)2D3] on the expression of AMH in cultured human luteinized granulosa cells (GCs).