Abstract
Coronary artery disease (CAD) is a leading cause of deaths of women and men worldwide. In this study we tried to assess the relationship between Vitamin D status and CAD. Vitamin D has a big role in the body and debate on its effect on the heart and coronary arteries still exits. C-reactive protein (CRP) is an inflammatory marker which may rise in CHD. Aim: To determine the relationship between Vitamin D status and CRP and CAD risk among patients at middle zone of the Gaza Strip. Methodology: A retrospective case-control, hospital-based study was conducted at Al-Aqsa Martyr’s Hospital in Dier El-Balah City from August 2014 to October 2014. Patients (n = 100) aged above 40 years with confirmed CAD history were recruited using a purposeful, non-random sampling. Vitamin D status assessed by food frequency questionnaire of dietary Vitamin D and serum Vitamin D. Serum Vitamin D was measured using Calbiotech’s 25-OH Vitamin D ELISA and serum CRP was measured by the latex agglutination. SPSS V.19 used for data analysis. Results: Mean of age among cases was (68.28 ± 8.01) higher than controls (57.82 ± 9.61) (P = 0.01); percent of males (54%) was higher than females (46.0%) among cases. Sun exposure and mean duration of daily exposure to sunlight were higher in cases (P > 0.05). Cases were consumed less servings of Vitamin D rich food than controls (P > 0.05). Percent of Vitamin D deficiency among cases (42%) was higher than controls (16.0%) (P = 0.002). Mean of serum Vitamin D in association with positive CRP was (79.95 ± 70.6) lower than those with negative CRP (106.06 ± 68.966) (P = 0.13). Percent of positive serum CRP among cases 30% was higher than controls 10% (P = 0.01). Conclusion: Vitamin D deficiency was associated with positive CRP in patients with CAD. Vitamin D may have an anti-inflammatory effect regarding to our results.
Highlights
Coronary artery disease (CAD) is global health problem which associated with multiple causes
This results in elevation of interleukin-6 and C-reactive protein (CRP) which may be detected in the peripheral circulation [8] [9]
Regarding to sun exposure and duration of daily sunlight exposure, we found a direct relationship between sun exposure and duration of exposure and risk for developing CAD, that percent of cases who was living in sunny houses was lower than controls with significant statistical difference
Summary
Coronary artery disease (CAD) is global health problem which associated with multiple causes. Atherosclerosis is a chronic inflammation of the arteries that develops under the action of risk factors It begins as qualitative changes in endothelial cells; under the action of oxidative, hemodynamic, or biochemical stimuli (such as smoking, hypertension, dyslipidemia) and inflammatory factors, they change their permeability to promote the entry and retention of blood-borne monocytes and low density lipoprotein (LDL) [4] [5]. The atherosclerotic lesion contains cytokines that provoke the production of many inflammatory and cytotoxic molecules in macrophages and vascular cells [6] and promote the antiatherosclerotic immune reactions [7]. This results in elevation of interleukin-6 and C-reactive protein (CRP) which may be detected in the peripheral circulation [8] [9]. CRP is an inflammatory marker that elevates in patients with CAD caused by inflammation in the coronary artery rather than in the ischemic myocardium [10] [11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
