VITAMIN D STATUS AND ITS CORRELATION WITH SYSTEMIC CYTOKINE LEVELS IN PEDIATRIC PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA

Abstract

The aim of present study was to establish correlations between vit D status and systemic cytokines profile in children with community acquired pneumonia (CAP). The prospective study was performed in 41 Children with CAP at age 5 to 15 years hospitalized in TSSU Zhvania Pediatric Academic Clinic between November 2019 to March 2021 (negative SARS-2-CoV). Vit D One moment blood concentrations of 25-hydroxyvitamin D were determined in every study participant. According to recent consensus, a 25(OH)D concentration <50 nmol/L, or <20 ng/mL was an indication of vitamin D deficiency, a 25(OH)D concentration of 50–75 nmol/L, or 20–30 ng/mL was considered to indicate insufficiency; concentrations >75 nmol/L to 250 nmol/L, or 20 ng/mL-100ng/mL was considered to be sufficient. Interleukin (IL) 6 and 10 were determined twice on first and fifth days of hospital admission in the blood of each patient. I group (11 cases) formed patients with vit D deficiency, II group (12 cases) with vit D insufficiency and control group (18 cases) formed hospitalized patients with sufficient vit D concentration. Normal values in healthy population for IL-6 2.9±0.3 pg/ml, for IL-10 1.32±1.5pg/ml.Data were analyzed using computer program SPSS 18 (SPSS INC., CHICAGO, IL, USA). Statistical significance was taken as p<0.05. Serum levels of IL-6 and IL-10 upon admission were significantly higher in every patient to compare to normal data. IL-6 in vit D deficient patients were significantly increased, as at admission, as on 5-th day of hospitalization compared with other groups. On 5-7th hospital day IL-6 in vit D insufficient and sufficient patients had already normalized to levels similar to those of healthy individuals. Whereas IL 10 level stay high in four patients who required intensive care for ARDS. Our results have shown that the systemic cytokines levels and IL6/IL/10 ratio are increased in CAP patient. Vit D plasma concentration affects systemic cytokines levels in the blood. Vit D deficiency (<20ng/ml) can be recognized as risk-factor for pneumonia severity.