Vitamin D status and features of the immune status in women with autoimmune thyroiditis in the postmenopausal period

Abstract

Objective — to establish the effect of hypoestro­genemia in women with AIT on immune parameters and levels of vitamin D. Materials and methods. In 53 women with AIT and drug-compensated hypothyroidism (28 at the age of 36.95 ± 1.78 years and 25—55.52 ± 1.56 years), the level of 25(OH)D in the blood, thyroid status by the levels of TSH and free T4 (ELISA),lymphocyte immunophenotype(CD3, CD4, CD8, CD16, CD22 were studied.Immunoregulatory index (CD4+/CD8+) was calculated. The correlation between vitamin D and subpopulations of lymphocytes in the reproductive and postmenopausal periods was assessed. Results and discussion. In postmenopausal women with AIT, there is a decrease in the relative blood level of the studied lymphocyte subpopu­lations compared to the reproductive period (within the reference norms). For CD3 and CD16, the di­­fference is significant (p < 0.05). The degree of decrease in the level of T-helpers (CD4) was more pronounced thanof T-suppressors (CD8), which helps to reduce antibody-forming CD22 and IRI. Vitamin D levels have declined from insufficiency in the reproductive period to deficiency in postmenopausal women. The correlation between vitamin D and subpopulations of lymphocytes has age-related characteristics. Conclusions. In women with AIT and vitamin D insufficiency,in the postmenopausal period vitamin level decreases to a deficiency status. The immunogram of women with AIT and inadequate levels of vitamin D in the postmenopausal period is characterized by an uneven decrease in lymphocyte subpopulations with an imbalance between them. In women with AIT, the correlation between vitamin D and subpopulations of lymphocytes have differences in the reproductive and postmenopausal periods.