Vitamin D serum levels in children with psoriasis

Abstract

Objective — to examine and analyze the vitamin D serum levels, namely 25(OH)D, in children with psoriasis.Materials and methods. 111 children with psoriasis aged 4 to 17 who underwent inpatient treatment were evaluated. The 25(OH)D serum levels in children with psoriasis were measured in an accredited laboratory. The diagnosis of psoriasis was made on the basis of clinical data and universally accepted diagnostic criteria. Calculation of BMI was calculated by the formula: BMI = weight/height2. The indicators were calculated using Microsoft Excel «Data Analysis» packet.Results and discussion. When assessing the vitamin D serum levels in 111 children with psoriasis, the mean concentration was found: (24.30 ± 0.81) ng/mL. The optimal vitamin D levels were reported only in 23 (20.72 %) children, insufficient — in 49 (44.14 %), and vitamin D deficiency was found in 39 (35.14 %) children. The greatest increase in vitamin D serum level was observed in children aged 16—17 ((31.34 ± 3.22) ng/mL) and 4—7 ((29.97 ± 1.70) ng/mL). Vitamin D serum deficiency in children with psoriasis was observed in September and March ((17.32 ± 0.36) and (17.60 ± 1.99) ng/mL, respectively) and was significantly lower than in other months. In children with psoriasis, an inverse correlation of the monthly vitamin D serum levels was found with the monthly numbers of exacerbations. The correlation coefficient was – 0.53.Conclusions. The research showed that almost 80 % of the children with psoriasis had lower serum levels of vitamin D than the optimal point and averaged to (24.30 ± 0.81) ng/mL. The study revealed that vitamin D deficiency in the blood serum of children with psoriasis can be one of the risk factors, which leads to the exacerbation of the disease.