Vitamin D receptor (VDR) gene polymorphism BsmI in Syrian breast cancer patients

Abstract

Vitamin D plays important roles mainly in bone, immune system, and cell growth. It binds to Vitamin D Receptor (VDR) to mediate the vitamin D pathway. The BsmI polymorphism is the most studied VDR gene polymorphism in cancer research. The association of this polymorphism with breast cancer risk was investigated in different populations, but so far there was no data available with respect to the Syrian population. This current study has investigated the distribution of VDR gene (BsmI) polymorphisms using a PCR-RFLP in the breast cancer in Syrian women. The genotype frequency of BsmI was 32% vs 35.7% for BB, 38% vs 53.6% for Bb and 30% vs 10.7% for bb in breast cancer patients and controls, respectively. The allelic frequency was 51% vs 62.5% for B and 49% vs 37.5% for b in patients and controls, respectively. The VDR polymorphism BsmI was significantly associated with increased breast cancer risk (OR = 3.068 (1.326–7.100)). This study showed that there was a significant correlation between BsmI polymorphism with the breast cancer in Syrian women.