Abstract
BackgroundVitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP.MethodsIn total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the VDR gene were selected and genotyped.ResultsThe results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted Odd ratio(OR) = 2.68, 95% Confidence interval(CI) = 1.28–5.62, P = 0.009) and rs7975232 CC genotype (Recessive model: adjusted OR = 2.25, 95% CI = 1.10–4.58, P = 0.026). Moreover, rs2239185 and rs7975232 (P < 0.01) showed significant cumulative effects on OLP risk.Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR = 3.11, 95% CI = 1.42–6.83, P = 0.005), compared with the AC haplotype.Conclusion: The rs2239185 and rs7975232 variants of VDR may influence OLP susceptibility, and VDR gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.
Highlights
Vitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP)
Increasing evidence suggests that single nucleotide polymorphisms (SNPs) in vitamin Drelated genes could affect the properties of vitamin D, such as its anti-carcinogenic effects [7]
The recessive genetic model computed by logistic regression analyses showed that rs2239185 and rs7975232 were significantly associated with OLP susceptibility
Summary
Vitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP. Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa mediated by T cells, whose etiology remains unknown. OLP, the typical clinical feature of which include white stripes, can manifest as reticular, papular, plaque-like, erosive, atrophic and bullous [2, 3]. Erosive-like lesions are considered to be the most threatening condition and are Previous studies have suggested that vitamin D (VD) deficiency may be associated with an increased risk of some inflammatory diseases, such as OLP and inflammatory bowel disease [5, 6].
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