Abstract
BackgroundThe term premenstrual syndrome (PMS) encompasses a variety of physical and psychological symptoms that are related to the menstrual cycle. The likelihood of developing this syndrome, along with its potential severity has been found to be linked to many environmental, nutritional, and genetic factors. ObjectiveWe aimed to evaluate the frequency of vitamin D receptor (VDR) - Fok1 Restriction fragment length polymorphism in young women complaining of PMS. Materials and methodsThe current study included evaluation of 340 female students by a validated questionnaire, anthropometric measurement, followed by collection of venous blood samples and DNA extraction. VDR-Fok1 polymorph was investigated by PCR then fragmentation by Fok1 restriction enzyme and finally detection of genotypes using agarose gel electrophoresis. Results and conclusionWe observed a significant association between VDR FokI polymorphism and PMS. However, on subgroup analysis by ethnicity, the FF genotype was more predominant among Arab women. ff mutation was associated with a significantly higher risk for PMS [OR = 3.72, 95% CI = 1.65–8.35, p ≤0.05] among non-Arabs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
