Vitamin D plus calcium supplementation increased serum 25(OH)D on reproductive age women workers

Abstract

ABSTRACT Objective To analyze the efficacy of calcium supplementation plus vitamin D on the improved concentrations of serum 25(OH)D and the blood pressure in working women of childbearing age. Methods The design used in this research was an experimental study (randomized control trial), with 39 subjects of women at childbearing age who met the inclusion criteria for the study. Subjects were randomly allocated into two treatment groups, the VDC group (400 IU of vitamin D plus 500 mg of calcium) and the VD group (400 IU of vitamin D). Supplements were consumed every day for 12 weeks. Results Prior to supplementation, the average level of serum 25(OH)D in the VDC group was (16.7 ± 4.5) ng/dL which was higher than the average level of serum 25(OH)D in the VD group which was (14.9 ± 5.1) ng/dL. After supplementation, the subjects of VDC group showed an average increased 3.6 ng/dL of serum 25(OH)D. The average increase of serum 25(OH)D in VD group was 6.3 ng/dL. The increase of serum 25(OH)D in VDC group was 21.6%, while in the VD group the increase was almost two times higher (42.3%) than that of the VDC group. Statistical test results showed that the average levels of serum 25(OH)D between the two treatment groups were significantly different. Conclusions The average systolic blood pressure prior to supplementation of the VDC group was (128.5 ± 22.5) mmHg which was slightly lower than that of the VD group [(131.1 ± 18.0) mmHg].