Abstract
Beyond its established role in calcium homeostasis, vitamin D acts as a neuroactive steroid. Our group has shown important effects of its physiologically active form, calcitriol, on mesolimbic dopamine (DA) systems in rodents, including increases in subcortical tyrosine hydroxylase, D2/3 receptors, and amphetamine-stimulated DA release and locomotion. However, calcitriol’s effects on midbrain DA function in humans are untested. We explored whether calcitriol enhances D2/3 receptors/subcortical DA release in healthy humans as measured by 11C-PHNO PET.
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