Abstract
The findings form studies on the relationship between vitamin D and type 2 diabetes were inconsistent. To elucidate the association between vitamin D consumption and type 2 diabetes risk by conducting a meta-analysis. We conducted a systematic literature search to identify prospective cohort studies of vitamin D intake and type 2 diabetes risk prior to November 2012. Eligible studies were retrieved via both computer searches and manual review of references. The summary risk estimates were calculated based on the highest versus the lowest categories. Meta-analysis of 4 prospective cohort studies involving 187, 592 participants and 9, 456 incident cases showed an absence of significant association between total vitamin D intake and type 2 diabetes risk. The combined RR was 0.93 (95% CI: 0.85-1.01). The associations were similar for subgroup analyses, a combined RR respectively was 0.94 (95% CI: 0.77-1.08), 0.91 (95% CI: 0.77-1.08), 0.93 (95% CI: 0.84-1.02), and 0.92 (95% CI: 0.84-1.01) for the intake of dietary vitamin D, supplemental vitamin D, total vitamin D in USA and total vitamin D for women only. Our results support that there was no association between vitamin D intake and type 2 diabetes.
Highlights
Diabetes mellitus is a group of metabolic diseases in which a person is characterized by high blood sugar producing the classical symptoms of frequent urination, increased thirst and increased hunger[1]
Meta-analysis of 4 prospective cohort studies involving 187, 592 participants and 9, 456 incident cases showed an absence of significant association between total vitamin D intake and type 2 diabetes risk
The associations were similar for subgroup analyses, a combined RR respectively was 0.94, 0.91, 0.93, and 0.92 for the intake of dietary vitamin D, supplemental vitamin D, total vitamin D in USA and total vitamin D for women only
Summary
Diabetes mellitus is a group of metabolic diseases in which a person is characterized by high blood sugar producing the classical symptoms of frequent urination, increased thirst and increased hunger[1]. Type 2 diabetes is caused by insulin resistance, a disease in which cells do not respond to the insulin properly, sometimes coupled with relatively insulin deficiency[2]. Type 2 diabetes mellitus is one of the 10 most prevalent diagnosed diseases in a representative US population of men older than 50 years of age, with a further increase of average 7 million people affected by diabetes each year[3]. There will be approximately 438 million developing diabetes by 2030, accounting for 4.4% of all age groups worldwide[4]. Smoking, ageing, obesity and physical inactivity are the wellknown risk factors for diabetes 5. The findings form studies on the relationship between vitamin D and type 2 diabetes were inconsistent
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