Abstract
BackgroundRecent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) serum levels and patient characteristics.MethodsA retrospective single-center study of 25OHD and 1,25(OH)2D serum concentrations in 50 children with PSIS at the initial evaluation before treatment.ResultsMean concentrations of 33.2 ± 18.0 ng/mL for 25OHD and 74.5 ± 40.7 ng/L for 1,25(OH)2D were measured. Additionally, 25OHD concentrations were significantly higher in boys than in girls (p = 0.04) and lower in the cold season than in the sunny season (p = 0.03). Significant positive correlations were observed between the GH peak and serum 1,25 (OH) 2D concentrations (Rho = 0.35; p = 0.015) and the 1,25(OH)2D/25OHD ratio (Rho = 0.29; p < 0.05). No correlation was found for other characteristics, including IGF1.ConclusionsVitamin D status in children with hypothalamic-pituitary deficiency due to PSIS was similar to that reported in national and European studies in healthy children. The positive significant correlations between the GH peak and the 1,25 (OH)2D concentration as well as with the 1,25 (OH)2D/25OHD ratio suggest that even in these patients who had severely impaired GH secretion and low IGF1 levels, an interplay between the GH/IGF1 axis and the vitamin D system still exists.
Highlights
Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1)
As we used various GH assays over the study period, we expressed the GH peak concentration in mU/L using conversion factors that were specific of the international standard used to calibrate the GH assay (i.e., 1 ng/mL = 2 mU/L for the assay calibrated with the old 66/217 international standard composed of poorly purified pituitary GH; 1 ng/mL = 2.6 mU/L for the assay calibrated against the 80/505 international standard composed of highly purified pituitary GH; 1 ng/mL = 3 mU/L for the assay calibrated against the 98/574 international standard composed of recombinant human (h)GH)
Significant positive correlations were observed between the GH peak level and serum 1,25 (OH)2D concentration (Rho = 0.35; p = 0.015) and the 1,25(OH)2D/25-hydroxyvitamin D (25OHD) ratio (Rho = 0.29; p < 0.05)
Summary
Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) serum levels and patient characteristics. Growth hormone (GH) deficiency (GHD) can be congenital or acquired. The concentration of serum 25OHD reflects the vitamin D status of an individual. Debate remains regarding the 25OHD level that defines the optimal level, vitamin D deficiency is considered to be common worldwide in both adults and children [8,9,10,11].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
