Abstract
Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin Dlevel in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin Dlevels were treated for 24 weeks with adose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin Dlevels were determined. In people with chronic pancreatitis, vitamin Dlevels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin Dwith gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin Dlevel to the level of the control group. Blood serum vitamin Dlevels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin Dsupplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29).
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