Abstract
Introduction: Vitamin D is a fat-soluble steroid prohormone. Vitamin D is an important regulator of calcium absorption and bone growth. Objectives: There is considerable controversy and conflicting studies on relationship between serum vitamin D in healthy individuals and ageing. The aim of this study is to test the relationship between serum 25-hydroxyvitamin vitamin D with age groups and gender in a group of Iranian healthy individuals. Patients and Methods: In this current cross-sectional study, 102 healthy individuals were selected. Serum vitamin D levels were measured using ELISA kit. According to the history and laboratory tests, patients with the history of diabetes, any active or chronic infections, liver disease, diabetes or malignancy were excluded from the study. Any history of administration of vitamin D was also an exclusion criterion. All participants had normal renal function detected by normal serum creatinine and blood urea nitrogen (BUN). To determine the relationship between gender (two categories) and age group (three categories) with vitamin D levels, Mann-Whitney U and Kruskal-Wallis tests were used respectively. Results: The average age of the participants was 42.97±15.54 years. The mean vitamin D level was 17.32±12.16 ng/mL. In this study, 73% of individuals had vitamin D deficiency, 18 % had marginal deficiency and 9% had a normal vitamin D levels. This study showed a significant relationship between vitamin D and age of subjects(r=0.23, P=0.02). Conclusion: High percentage of vitamin D deficiency in the participants of our study requires more attention to this public health entity. A direct relationship between serum vitamin D level and the age of healthy individuals requires further investigation.
Highlights
Vitamin D is a fat-soluble steroid prohormone and is formed when the skin is exposed to the ultra-violet radiation
Implication for health policy/practice/research/ medical education In a study on 102 healthy participants, we found a significant relationship of vitamin D with age of subjects (r = 0.23, P = 0.02)
In this study we found a significant relationship between vitamin D and age of subjects(r = 0.229, P = 0.02; Figure 1)
Summary
Vitamin D is a fat-soluble steroid prohormone and is formed when the skin is exposed to the ultra-violet radiation. The molecule of 7-dehydrocholesterol presents in skin and absorbs the UV radiation to produce cholecalciferol and transfers it to the liver. As it is turned into 25-hydroxyvitamin vitamin D in the liver, it is released into the blood and reaches to the kidneys. Vitamin D plays an important role in preventing some types of diseases such as colon and prostate cancers, osteoporosis and diabetes type 1 (1-3). It is interacted in chronic obesity-related diseases such as cardiovascular diseases, hypertension and mellitus diabetes (2,3). Other risk factors including having dark skin color, winter, living in a location with high geographical latitude, using sunscreens, exposure to air pollution, clouds or fog (2-4)
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