Abstract
VitaminD deficiency has been associated with apoor outcome in patients with heart failure (HF). We examined the role of vitaminD in the response of HF patients to cardiac resynchronization therapy (CRT). The study comprised 50patients (30men and 20women) with HF undergoing CRT implantation who were prospectively enrolled. Response to CRT was defined as acombination of ≥15% reduction in left ventricular end-systolic volume (LVESV) and ≥10% improvement in the 6‑Minute Walk Test within 6months. Patients were grouped based on their levels of vitaminD prior to CRT implantation. Clinical and echocardiographic examinations were performed prior to and 6months after the procedure. Of the patients, 11 (22%) failed to respond to CRT; two patients died within 6months and an additional nine patients showed no improvement in the 6‑Minute Walk Test and no reduction in their baseline LVESV. A comparison was made between 25patients with sufficient levels of vitaminD and 25patients with insufficient levels. Nine patients (36%) in the "insufficient" group and two patients (8%) in the "sufficient" group failed to respond to CRT implantation (p= 0.037). Adequate serum concentrations of vitaminD play asignificant role in improving the functional status of patients with systolic HF following CRT implantation.
Published Version
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