Vitamin D Deficiency and Chronic Lung Disease

Christopher R Gilbert,Cecilia M Smith,Seth M Arum

doi:10.1155/2009/829130

Abstract

Vitamin D deficiency is increasingly being recognized as a prevalent problem in the general population. Patients with chronic lung diseases such as asthma, cystic fibrosis, chronic obstructive lung disease and interstitial pneumonia appear to be at increased risk for vitamin D deficiency for reasons that are not clear. Several studies indicate that vitamin D possesses a range of anti-inflammatory properties and may be involved in processes other than the previously believed functions of calcium and phosphate homeostasis. Various cytokines, cellular elements, oxidative stress and protease/antiprotease levels appear to affect lung fibroproliferation, remodelling and function, which may be influenced by vitamin D levels. Chronic lung diseases such as asthma and chronic obstructive lung disease have also been linked to vitamin D on a genetic basis. This immune and genetic influence of vitamin D may influence the pathogenesis of chronic lung diseases. A recent observational study notes a significant association between vitamin D deficiency and decreased pulmonary function tests in a large ambulatory population. The present review will examine the current literature regarding vitamin D deficiency, its prevalence in patients with chronic lung disease, vitamin D anti-inflammatory properties and the role of vitamin D in pulmonary function.

Highlights

Vitamin D deficiency is increasingly being recognized as a prevalent problem in the general population
La présente analyse contient un examen des publications courantes au sujet de la carence en vitamine D, de sa prévalence chez les patients atteints d’une maladie pulmonaire chronique, des propriétés antiinflammatoires de la vitamine D et du rôle de la vitamine D dans la fonction pulmonaire
Vitamin D anD Lung Disease The effect that 25-hydroxyvitamin D levels in patients with chronic lung disease may have on pulmonary function has not been extensively studied

Summary

La carence en vitamine D et la maladie pulmonaire chronique

Vitamin D deficiency is increasingly being recognized as a prevalent problem in the general population. Cellular elements, oxidative stress and protease/antiprotease levels appear to affect lung fibroproliferation, remodelling and function, which may be influenced by vitamin D levels Chronic lung diseases such as asthma and chronic obstructive lung disease have been linked to vitamin D on a genetic basis. La présente analyse contient un examen des publications courantes au sujet de la carence en vitamine D, de sa prévalence chez les patients atteints d’une maladie pulmonaire chronique, des propriétés antiinflammatoires de la vitamine D et du rôle de la vitamine D dans la fonction pulmonaire Lung diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), asthma and the idiopathic interstitial pneumonias are common chronic diseases in the United States and worldwide. The present article will review the literature regarding the role and prevalence of vitamin D deficiency in patients with chronic lung disease, along with potential mechanisms for the involvement of vitamin D in lung disease

ChroniC Lung Disease anD infLammation

Findings

Vitamin D effeCts beyonD bone metaboLism