VITAMIN D DEFICIENCY AND CARDIOVASCULAR RISKS IN DIABETES PATIENTS

Abstract

Low vitamin D levels in diabetic patients are associated with an increased risk of cardiovascular disease. Diabetic patients in Kerala are at increased risk for cardiovascular disease due to low vitamin D levels. The prevalence of cardiovascular diseases (CVD) is rising worldwide. Recent research reveals that Vitamin-D (Vit-D) insufciency may contribute to advancing cardiovascular illnesses, even if the impact of conventional risk factors is already well-established. Diabetes mellitus (DM) is an established risk factor for cardiovascular disease (CVD). It has been observed that the frequency of diabetes mellitus and vitamin D insufciency is relatively high in the population of Kerala. To determine if the status of vitamin D inuences the evolution of cardiovascular risk in patients with diabetes in the given population, this research was conducted. A cross-sectional study was undertaken at a teaching hospital for tertiary care. The test population consisted of persons with diabetes, whereas the control group consisted of age- and sex-matched healthy adults. Each patient's demographic information, blood pressure, and blood samples were obtained. The lipid prole, blood glucose level, Apo-A1, and Apo-B were analyzed using the collected samples. The acquired results were evaluated using a suitable statistical instrument. Ahigher value for lipid prole in the test population suggests a greater risk for CVD in the test population, according to the results. Apo-A1 levels were substantially lower, and Apo-B levels were signicantly more signicant in the test population compared to the control group, indicating that the test population is at an elevated cardiovascular risk. The research revealed a negative connection between vitamin D and cardiac indicators, suggesting a role for vitamin D deciency in cardiovascular disease. The analysis of biomarkers in the various test groups revealed a statistically signicant difference based on Vit-D status. The correlation between Vit-D status and CVD is established, and the results are comparable to previous research abroad. The present investigation indicated a strong correlation between Vit-D concentration and CVD risk in the population of Kerala. The study showed that the test group had increased levels of both traditional and novel biomarkers for predicting cardiovascular risk. To determine the prevalence of this association, future prospective follow-up research must be done.