Abstract

We investigated the prevalence of vitamin D deficiency among individuals who have a history of tuberculosis (TB) diagnosis in Korea. Using the 5th Korean National Health and Nutrition Examination Survey, we selected 805 individuals with a history of TB diagnosis and 16,049 controls without a history of TB. Vitamin D deficiency was defined as a 25(OH)D level less than 20 ng/mL. Vitamin D deficiency was revealed in 71.7% of the individuals with a history of TB diagnosis and in 72.1% of the controls. Vitamin D deficiency was more likely in women than in men, in people who engaged in other jobs or were unemployed than in people who engaged in skilled agricultural, forestry, and fishery jobs, and in people who walked 3–5 days per week than in people who walked 6–7 days per week. Vitamin D deficiency was highly prevalent in the TB group. Regular examination and strategies to increase vitamin D levels in individuals with a history of TB are needed, as vitamin D is associated with TB conditions and bone disease.

Highlights

  • Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is a serious problem around the world

  • Vitamin D deficiency was highly prevalent in the TB group

  • Vitamin D deficiency has been reported to be associated with cancer [5] as well as chronic diseases like hypertension [6], autoimmune disease [7], and diabetes [8]

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Summary

Introduction

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is a serious problem around the world. In 2014, the total number of TB cases in the world stood at 9.6 million, and the number of TB-related deaths was 1.5 million [1]. Vitamin D is an important hormone for skeletal growth and maintenance. It maintains mineral homeostasis and plays an important role in various tissues [4]. Vitamin D produced from the skin is prone to deficiency nowadays due to modern lifestyles. Vitamin D deficiency has been reported to be associated with cancer [5] as well as chronic diseases like hypertension [6], autoimmune disease [7], and diabetes [8]

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