Abstract
, so the only reliable therapy is proper surgical excision when the disease is localized to the skin.Therefore, the management of meta-static melanoma represents a significant challenge for both clinicians and patients, and there is an urgent need to clarify the mechanisms responsible for resistance to therapy against metastatic melanoma . These challenges undoubtedly will be addressed by basic and clinical melanoma researchers for years to come. However, to help patients with these devastating diseases we need immediate, nontoxic and economical adjuvant strategies for improvement of patient survival, with rela -tively limited side effects. These require-ments can be met by the application of natural products and their derivatives in an educated fashion, to not only restrict mel -anoma growth and progression but also to restore the body’s homeostatic capabilities to control tumor behavior
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