Abstract

Osteoarthritis occupies a leading position among the causes of disability in patients with rheumatic diseases. The wide prevalence of pathology and the high risk of disability predetermine the need to prevent its development, improve the effectiveness of treatment and conduct rehabilitation measures. The article presents a clinical case on the use of vitamin D and its active metabolites, polynucleotide preparations in the treatment of osteoarthritis. Long-term intake of high doses of vitamin D leads to a decrease in the intensity of pain and functional deficit in patients with osteoarthritis. Vitamin D and its active metabolites compensate for the deficiency of cholecalciferol and thereby reduce the intensity of synovial inflammation in osteoarthritis, at maximum dosages demonstrate a chondroprotective effect by inhibiting apoptosis of chondrocytes, and in the early stages prevent non-adaptive remodeling of the subchondral bone. The results of fundamental and randomized clinical trials allow us to conclude that it is advisable to include vitamin D in the complex therapy of osteoarthritis. It is important to include vitamin D in complex therapy in the early stages of the disease. In addition, there is information in the literature about the use of polynucleotide preparations in the treatment of osteoarthritis. Against the background of treatment with polynucleotide preparations, it is possible to delay the time to arthroplasty, and the need to take non-steroidal anti-inflammatory drugs and opioids decreases.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.