Vitamin D and Hematological Indicators of Inflammation in Prediabetes

Abstract

Objectives: Prediabetes is characterized by the presence of inflammation. Hematological parameters provide the advantageous qualities of being cost-effective and readily reproducible, rendering them highly helpful for the purpose of disease surveillance. The impact of vitamin D on inflammatory mediators and its role in the progression from prediabetes to type 2 diabetes has been seen. This study aims to investigate hematological markers, glycemic management, and vitamin D status among individuals with prediabetes. Methods: A retrospective investigation was performed on a cohort of 270 persons with prediabetes (5.7-6.4% glycated hemoglobin levels) and 299 participants with normal blood glucose levels. In order to conduct a comparison of hematological indicators between two groups, statistical analyses including chi square analysis and the t test were employed. The analysis of variance (ANOVA) statistical method was employed to analyze the components within three distinct categories of Vitamin D levels: acceptable (more than 75 nmol/L), inadequate (ranging from 50 to 74.9 nmol/L), and deficient (50 nmol/L). The odds ratio for prediabetes was obtained through the utilization of regression analysis. Results: The study observed a statistically significant decrease in vitamin D levels among individuals with prediabetes (mean 57.91 ± 20.83, p = 0.05). The group of individuals with prediabetes exhibited significantly higher values for the neutrophil lymphocyte ratio (2.10 ± 0.85; p = 0.05), platelet lymphocyte ratio (137.70 ± 43.70; p = 0.05), mean platelet volume (8.55 ± 3.00; p = 0.001), and red cell distribution width (12.65 ± 1.31; p = 0.05). The present study observed a statistically significant positive correlation between declining levels of vitamin D and increasing trends in the neutrophil lymphocyte ratio, platelet lymphocyte ratio, and red cell distribution width in individuals with prediabetes. The study revealed that the mean platelet volume had a noteworthy association with the development of prediabetes. Conclusions: The neutrophil lymphocyte ratio, platelet lymphocyte ratio, red cell distribution width, and mean platelet volume are emerging inflammatory markers that can be employed for monitoring purposes in patients with prediabetes. However, it is important to note that these indicators should be utilized in combination with an assessment of Vitamin D status.