Abstract
Vitamin D and environmental factors in multiple sclerosis
Highlights
Multiple sclerosis is an autoimmune disease of unknown etiology carrying high social burden
The immune system related process is characterized by antigen specificity in the central nervous system (CNS):myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), proteolipid protein (PLP), myelin associated glycoprotein (MAG); altered immune response by Th1 and Th17 mediated diss eminated inflammation of central myelin structures with imbalance in cytokine secretion of Th1, Th17 and Th2 lymphocytic (Ly) subpopulations
Slavov GS (2016) Vitamin D and environmental factors in multiple sclerosis for the status of vitamin D is the serum concentration of 25(OH)D, correlating with the level of 1,25(OH)2D [5] The standard reference range for 25(OH)D of 70-80 nmol/l has been determined by studying calcium metabolism; it ensures that normal calcium homeostasis is maintained
Summary
Georgi S Slavov1*, Anastasiya G Trenova, Mariya G Manova, Ivanka I Kostadinova, Tonka V Vasileva and Zahari I Zahariev1 1Department of Neurology, Medical Univer¬sity, Plovdiv, Bulgaria 2Department of Pharmacology and Clinical Pharmacology, Medical Univer¬sity, Plovdiv, Bulgaria
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