中枢電気活動と腸管運動に及ぼす活性Vitamin B<SUB>1</SUB>および糖質の影響

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Effects of maltose, glucose and vitamin B1 on the central nervous system and intestinal movement were electrophysiologically examined by use of rabbits.1. On the arousal reaction and the evoked muscular discharge induced by stimulation of the brain stem reticular formation, and on the inhibitory effect of arousal reaction toward intestinal movement, activated vitamin B1,50%glucose and maltose mainly showed inhibitory effect. On the contrary, they showed facilitatory effect on the intestinal movement.2. On the evoked muscular discharge of fore and hind limbs induced by stimulation of the cerebral cortex, the small amount of 50%glucose and maltose showed inhibitory effect, on the contrary, the great amount of 50%glucose and maltose showed facilitatory effect, and activated vitamin B1 showed both inhibitory and facilitatory effect in which no certain tendency was recognized.3. On the evoked muscular discharge induced by stimulation of the hippocampus,50% glucose and maltose showed facilitatory effect, on the other hand, activated vitamin B1 mainly showed inhibitory effect. Thus carbohydrate solution and activated vitamin B1 showed opposite effects.4. On the early components (N1, N2) of afferent average evoked potentials of the cerebral cortex induced by the sciatic nerve stimulation, activated vitamin B1,50% glucose and maltose showed facilitatory effect. On the contrary, they showed no significant effect on the late components (N4, N5).5. On the nociceptive reflex induced from the tibialis anterior muscle due to stimulation of the tibial nerve, activated vitamin B1,50%glucose and maltose showed facilitatory effect.6. On the H wave induced from M. gastrocnemius tibialis due to stimulation of the sciatic nerve, maltose,50%glucose and activated vitamin B1 showed facilitatory effect in which activated vitamin B1 and 50%glucose showed stronger effect than maltose. On the M wave the activated vitamin B1 and 50%glucose showed facilitatory effect, when compared with the effect on the H wave, effect on the H wave is considered stronger. Maltose showed no significant effect on the M wave.7. Activated vitamin B1,50%glucose and maltose increased more than 30% the threshold of arousal reaction and evoked muscular discharge due to stimulation of the reticular formation.5 %glucose slightly increased the threshold.From these completed results, it is revealed that activated vitamin B1 and carbohydrate (administrated at the same time) on one hand, showed facilitatory effect on the afferent pathway and the intestinal movement, but that on the other hand, they might show the inhibitory effect on the arousal reaction. The countermeasure has been discussed.