Abstract

Vitamin B12 is a water-soluble nutrient involved in several important physiologic processes. Deficiency may lead to a variety of manifestations, such as megaloblastic anemia and neurologic deficits.1 Gastric acid plays a role in vitamin B12 absorption by activating proteolytic enzymes in the stomach, such as pepsin, which free protein-bound vitamin B12 from food sources to make it available for absorption.2,3

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