VITAMIN B12 BINDING CAPACITY OF SERUM IN B12 DEFICIENCY.

Abstract

Summary1. Human serum has been found to have a limited binding capacity for Vit. B12. The B12 binding protein, a seromucoid fraction, appears to be normally only approximately 30-40% saturated. In Vit. B12 deficiency the unsaturated binding capacity is normal but total binding capacity is diminished. 2. It is postulated that; the slower than normal disappearance of Co57-B12 from the plasma of B12 deficient individuals is caused by diminished binding capacity in the tissues.The authors wish to express their appreciation to Medical Illustration Service, VA West Side Hospital and to Mr. Lemuel Hall for technical assistance.