Abstract
Vitamin B1, or thiamine, is one of the most relevant vitamins in obtaining energy for the nervous system. Thiamine deficiency or lack of activity causes neurological manifestations, especially symptoms of depression, intrinsic to multiple sclerosis (MS) and related to its pathogenesis. On this basis, the aim of this study was to determine the possible relationship between the nutritional habits of patients with MS and the presence of depression. Therefore, a cross-sectional and observational descriptive study was conducted. An analysis of dietary habits and vitamin B1 consumption in a Spanish population of 51 MS patients was performed by recording the frequency of food consumption. Results showed a vitamin B1 intake within the established range, mainly provided by the consumption of ultra-processed products such as cold meats or pastries, and a total carbohydrate consumption lower than recommended, which stands out for its high content of simple carbohydrates deriving from processed foods such as dairy desserts, juice, snacks, pastries, chocolate bars, soft drinks and fermented alcohol. In addition, a significant negative correlation between depression and the intake of thiamine and total carbohydrates was observed. These findings could explain the influence of MS patients’ eating habits, and consequently vitamin B1 activity, on depression levels.
Highlights
Multiple sclerosis (MS) is a degenerative autoimmune disease of the central nervous system (CNS)characterized by inflammatory demyelination and axonal loss [1], being affected by mitochondrial function [2]
Based on the above evidence, the aim of this study is to determine the balance of food intake related to vitamin B1 and its relation to depression in a population with multiple sclerosis (MS)
After applying the selection criteria specified in the Material and Methods section, and considering the withdrawal of 16 subjects, a sample of 51 MS patients with an average weight of 71.2 kg was analyzed
Summary
Characterized by inflammatory demyelination and axonal loss [1], being affected by mitochondrial function [2]. It represents the main cause of disability in young adults, with a higher prevalence in women (an approximate ratio of 3:1) [3]. Disability and fatigue are characteristic of the disease [6]. Are usually accompanied by emotional disturbances [7]. Concerning these emotional problems, 50% of patients with MS have depression (2–3 times higher compared to the general population) [8].
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