Abstract
In this study we evaluated the variations in vitamin B namely cyanocobalamin, folate and pyridoxine, choline,protein and glucose-6-phosphate dehydrogenase (G6PD) activity in cervical cancer patients at pretherapy, when patients showed up at the clinic and at various times after the commencement of chemotherapy and radiotherapy (using one month and two months respectively). The subjects comprised 32 patients who had visited the Department of Radiotherapy and had been diagnosed with cancer of the cervix (cervical cancer) and 32 age matched control.There was a significant (ρ<0.05) decrease in the B vitamins and choline in the different groups relative to control.There was a marked variation in plasma protein at two months compared to control and G6PD significantly decreased (ρ<0.05) at one month and two months of treatment relative to control. The study showed the relationship between low levels of vitamin B group, choline, G6PD and plasma protein with cancer progression and changes accompanying treatment and a probable need for supplementation with immune boosters during therapy.
Highlights
Cervical cancer is the second most common cancer in women all over the word, next to breast cancer; around half a million new cases are diagnosed and over two hundred thousand deaths are attributed to the disease annually [1]
This work was done to estimate the effect of radiotherapy and chemotherapy, at different periods of treatment, on vitamins B12, B6, B9, choline, glucose-6-phosphate dehydrogenase (G6PD) activity and plasma protein content of cervical cancer patients and their age/weight matched controls at varying times after the commencement of treatment
Anthropometric measurements were taken for the patients at pretherapy, one month and two months respectively while that of the controls was once, the height in meters and weight in kg was used to calculate the body mass index (BMI) and the results are shown on Table 1
Summary
Cervical cancer is the second most common cancer in women all over the word, next to breast cancer; around half a million new cases are diagnosed and over two hundred thousand deaths are attributed to the disease annually [1]. HPV infection is common, only a small proportion of HPV infections persist and go on to promote the development of invasive cervical cancer. Other factors must influence the susceptibility to infection with HPV and the development of HPV-induced neoplastic changes to invasive cervical cancer. Folate and vitamin B12 may have modulating effect in the risk cervical cancer development. Folate has been recognized as a contributing factor to ensure reproductive health and there is a growing body of evidence that reduced dietary folate may increase the risk of cervical cancer. The above informed our decision to evaluate the levels of folate, choline, pyridoxine and cyanocobalamin, using high performance liquid chromatography (HPLC) a very rapid assay method, protein and glucose-6-phosphate dehydrogenase (G6PD) using biochemical assay of the parameters in plasma of both patients and healthy controls at both pretreatment of disease and at varying times after the commencement of therapy
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