Abstract
To test its effectiveness as an indicator of vitamin-B-6 deficiency erythrocyte glutamic-pyruvic transaminase (EGPT) activity with or without stimulation by pyridoxal phosphate (PALPO) was measured in vitro in a group of 11 control females and 13 females using oral contraceptives. It had been suggested oral contraceptive users may be vitamin-B-6 deficient. Mean basal EGPT activity was significantly lower for contraceptive users (p less than .02) while percentages of stimulation by PALPO were significantly greater than those recorded for the controls (p less than .001). Mean values of EGPT activity with PALPO stimulation were not significantly different between the 2 groups. It is apparent that vitamin-B-6 depletion occurs with use of oral contraceptives and that EGPT with PALPO stimulation is a valid method of determining the vitamin-B-6 status in women using oral contraceptives.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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