Vitamin and Endocrine Therapy in Nausea and Vomiting of Pregnancy

Abstract

Summary Fourty-three patients received pyridoxine hydrochloride ( B6 ) in doses of 50 to 100 mg. intravenously. Of this group twenty–five were primigravidas and eighteen were multigravidas. Eighteen, or roughly three–fourths of the primigravidas were completely relieved, while only six, or one–third of the multigravidas were relieved. Of the seven complete failures, five were multigravidas. Thirteen of the group had partial relief of which six were primigravidas and seven were multigravidas. .A total of sixty–six patients received combined doses of thiamin hydrochloride and pyridoxine hydrochloride in doses ranging from 50 mg. to 100 mg. of each. Of this group, nine had previously received pyridoxine alone with partial or no relief at all. In this group there were twenty–seven multigravidas and thirty–nine primigravidas. Thirty–one of the primigravidas were completely relieved; there were two complete failures, while six others had varying degrees but definite relief. Fifteen multigravidas were completely relieved and seven were not benefited, while five reported partial relief. Five patients who were not benefited by vitamins were given adrenal cortex extract. The usual dose was 2 c.c. given subcutaneously at daily intervals. Three felt better and were able to retain food.