Abstract
The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNγ) and Treg (TGF-β, IL-10) related cytokines in obese and non-obese women. In a randomized double blind placebo controlled design, 56 obese women were randomly assigned to receive either an oral dose of 25,000 IU retinyl palmitate or placebo per day for 4 months. Twenty eight ages matched non-obese women were also received vitamin A. At the study entry, anthropometric variables were measured and serum Th17 and Treg related cytokine profile were determined at baseline and 4 months after intervention. Significantly higher baseline concentrations of IL-6 were observed in obese compared with non-obese women (P < 0.05). However, the initial concentrations of other cytokines were not significantly different between groups. The mean concentrations of IL-17 and TGF-β were significantly decreased after vitamin A supplementation in non-obese and obese women respectively. Positive relationships between IL-17 and IL-10 (r = 0.42, P < 0.001), TGF-β and IL-17 (r = 0.35, P < 0.001) and between IL-10 and IFN-γ (r = 0.41, P = 0.002) in total participants were also observed. The results of the present study showed for the first time that vitamin A supplementation reduces serum concentrations of IL-17 and TGF-β in reproductive age women. Further studies are needed to explore the possible underlying mechanisms.
Highlights
Obesity, the modern chronic disease of twenty-first century, is rapidly increasing worldwide in developing countries
Six withdrawals were in obese groups (3, irregular use of supplement or placebo, 2, impossibility to be present at appointment and 1, unwillingness to continue the trial)
Serum IL-10 concentrations significantly decreased in non-obese vitamin A treated group and serum IL-6 concentrations after intervention reduced in all three groups
Summary
The modern chronic disease of twenty-first century, is rapidly increasing worldwide in developing countries. We explore the effect of vitamin A supplementation on serum Th17/Treg related cytokines in obese women. General characteristics of study participants are presented in Weight, BMI, WC, HC and WHR in obese groups were significantly higher than non-obese group. Baseline concentrations of IL-6 were significantly higher in obese than non- obese group.
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