Abstract

IntroductionEach year, rabies causes approximately 59,000 deaths worldwide, including approximately two deaths in the United States. Before 1960, dogs were a common reservoir of rabies in the United States; however, increasingly, species of wildlife (e.g., bats, raccoons) are the main reservoirs. This report characterizes human rabies deaths, summarizes trends in rabies mortality, and highlights current rabies risks in the United States.MethodsRabies trends in the United States during 1938–2018 were analyzed using national rabies surveillance data. Data from the Healthcare Cost and Utilization Project for 2006–2014 were used to estimate the number of postexposure prophylaxis (PEP) visits per 100,000 persons during 2017–2018. The Centers for Medicare & Medicaid Services’ average sales price data were used to estimate PEP costs.ResultsFrom 1960 to 2018, a total of 125 human rabies cases were reported in the United States; 36 (28%) were attributed to dog bites during international travel. Among the 89 infections acquired in the United States, 62 (70%) were attributed to bats. In 2018, approximately 55,000 persons sought PEP after contact with a potentially rabid animal.Conclusions and CommentsIn the United States, wildlife rabies, especially in bats, continues to pose a risk to humans. Travelers also might be exposed to canine rabies in countries where the disease is still present; increased awareness of rabies while traveling abroad is needed. Vaccinating pets, avoiding contact with wildlife, and seeking medical care if one is bitten or scratched by an animal are the most effective ways to prevent rabies. Understanding the need for timely administration of PEP to prevent death is critical.

Highlights

  • Each year, rabies causes approximately 59,000 deaths worldwide, including approximately two deaths in the United States

  • Rabies can be prevented with timely administration of postexposure prophylaxis (PEP)

  • Dog bites acquired during international travel were the cause of 36 cases

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Summary

Introduction

Rabies causes approximately 59,000 deaths worldwide, including approximately two deaths in the United States. Results: From 1960 to 2018, a total of 125 human rabies cases were reported in the United States; 36 (28%) were attributed to dog bites during international travel. In the United States, several variants, or strains, of rabies virus circulate in animal reservoirs, including raccoons, skunks, foxes, and bats [1]. Regardless of the variant or animal reservoir, is fatal in over 99% of cases, making it one of the world’s most deadly diseases. Prompt administration of postexposure prophylaxis (PEP), consisting of rabies vaccine and immune globulin, immediately after exposure effectively prevents disease [1,2]. The elimination of canine rabies virus variant (CRVV) from the United States is one of the most important public health successes of the 20th century. By the late 1960s, fewer than 500 rabid dogs and three human rabies cases were reported annually [5]

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