Vital Dyes in Vitreoretinal Surgery—Chromovitrectomy Eds: C.H. Meyer 164 pp., hard cover ISBN 978-3-8055-8551-4 Karger Verlag

Abstract

The hardcover book “Vital Dyes in Vitreoretinal Surgery— Chromovitrectomy”, edited by C. H.Meyer is a multiauthored book encompassing 164 pages divided into 12 chapters. The book is volume No 42 in the book series “Developments in Ophthalmology”, edited by W. Behrens-Baumann. The book begins with a tribute to Prof. Peter Kroll, to whom editor Carsten Meyer dedicates this book for his lifetime achievements. Prof Kroll was head of the department of ophthalmology at the university of Marburg, Germany, a reknowned retina specialist and former teacher of the editor. The sequence of the book chapters appears logical. The first three chapters are focusing on the vitreous, followed by chapters on ICG use in peeling procedures, and closing with chapters on new dyes, recommendations for safe clinical application of new dyes and latest developments in this field. The first chapters about the vitreous include wellillustrated embryologic and histological descriptions, and both in vitro and in vivo visualization techniques using OCT-SLO combination techniques, presented by Jerry Sebag. Eduardo Rodrigues and co-workers present in their chapter an overview of the evolution of vital dyes in vitreoretinal surgery. Intraoperative images of vitreous staining with triamcinolone, autologous blood or preoperative intravenous fluorescein application are shown by Jorg Schmidt and co-workers. The next chapters describe biostaining with indocyanine green (ICG). Here a very detailed review is presented by Salvatore Grisanti and coworkers, including 192 literature quotes, on controversies and scientific data regarding ICG use in macular surgery, ranging from aspects like ICGconcentration, -dye persistence, -osmolarity, -sodium content to illumination effects. In the subsequent chapter, Arnd Gandorfer and coworkers focus on ICG toxicity, and Gregor Wollensak describes biomechanical considerations of ICG use. The following chapters report clinical experience and biochemical properties with the alternative stains Trypan Blue, Patent Blue V and Brilliant Blue G. Michel Farah and co-workers summarize the current knowledge of Trypan Blue, and Stefan Mennel and coworkers present data on the Trityl dyes Patent Blue V and Brilliant Blue G on the RPE and blood–retina barrier, with promising results particularly for Brilliant blue G. Hiroshi Enaida and Iatsuro Ishibashi present their detailed animal model evaluations and first clinical results with Brilliant Blue G in humans. The final three chapters focus on new developments in dyes and novel applications. Timothy Jackson provides here a sound overview on different vital stains and their potential target structures. He describes interesting techniques to identify clinical invisible retinal holes using vital stains either in the vitreous cavity or in the subretinal space. The next chapter addresses safety aspects of introducing new dyes for vitreoretial surgery. Christos Haritoglou and coworkers define here safety parameters that should be analyzed before dyes are being tested in humans. They range from light absorption properties of dyes, cell culture models to the selection of appropriate animal models. A. W. A. Weinberger (*) RWTH Aachen University, Department of Ophthalmology, Pauwelsstr. 30, 52074 Aachen, Germany e-mail: aweinberger@ukaachen.de