Abstract
Robust Ca2+ absorption is controlled by the highly Ca2+-permeable channels TRPV5 and TRPV6 in the kidney and intestine of terrestrial vertebrates, to fulfill the body's demand for Ca2+. Recently, a pathogenic role of TRPV6 was revealed in alcohol-associated endotoxemia; the intestinal barrier function is compromised by oxidative stress via TRPV6-mediated Ca2+ dysregulation. TRPV6-mediated Ca2+ absorption vital to maintain homeostasis is vulnerable to alcohol-induced malactivation.
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