Abstract
The oral microbiome contains numerous bacteria, which directly or indirectly participate in various human functions and continuously exchange signals and substances with the human body, significantly affecting human life cycle, health, and disease. This study aimed to conduct bibliometric studies on the scientific outputs of global oral microbiome research by Citespace software. The data were obtained from the Thomson Reuters' Web of Science Core Collection (WoSCC), from the first relevant literature published until December 31st, 2019, and a total of 2225 articles and reviews were identified. The top country and institutions are the United States and Harvard University. Keywords analysis showed that periodontal disease, oral microbes, and dental plaque are research hotspots. The burst word analysis indicates that early childhood caries, squamous cell carcinoma, gut microbiome, Helicobacter pylori, Candida albicans, and dysbiosis are likely to become the research hotspots of the next era. We also recommend the use of knowledge mapping methods to track specific knowledge areas efficiently and objectively regularly, which can accurately identify hotspots and frontiers and provide valuable information for practitioners in the field, including related scientists, students, journals, and editors.
Highlights
The term “human microbiome” refers to trillions of commensal, beneficial, and pathogenic bacteria that occupy the human body.[1]
This study investigates the global scientific outputs of the oral microbiome until December 31st, 2019
We analyzed data obtained from the Web of Science Core Collection (WoSCC) on multiple perspectives: publication outputs, countries, institutions, authors, co-cited journals, and keywords
Summary
The term “human microbiome” refers to trillions of commensal, beneficial, and pathogenic bacteria that occupy the human body.[1] It is often presented as common knowledge that, human microbiome outnumbers human cells by at least 10-fold, the ratio between them may be closer to 1:1 according to the recent studies,[2] and the MedComm. The human microbiome has been recognized as “supraorganisms” of the human body.[3]. Accumulating data have shown that the oral microbiome contributes to the development of oral diseases such as dental caries and periodontal diseases,[8] and involves in systemic diseases such as diabetes, cardiovascular diseases, rheumatoid arthritis, preterm birth, respiratory diseases, colorectal cancer, inflammatory bowel diseases, and Alzheimer’s disease, etc.[9,10,11] More importantly, a robust interplay between oral microbiome with the gastrointestinal tract has been recently well documented, concerning the role of oral anaerobes in the development and progression of colorectal carcinoma.[10,12,13,14,15]
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