Abstract
.Significance: Evaluation of vessel patency and blood flow direction is important in various medical situations, including diagnosis and monitoring of ischemic diseases, and image-guided vascular surgeries. While optical coherence tomography angiography (OCTA) is the most widely used functional extension of optical coherence tomography that visualizes three-dimensional vasculature, inability to provide information of blood flow direction is one of its limitations.Aim: We demonstrate two-dimensional (2D) transverse blood flow direction imaging in en face OCTA.Approach: A series of triangular beam scans for the fast axis was implemented in the horizontal direction for the first volume scan and in the vertical direction for the following volume scan, and the inter A-line OCTA was performed for the blood flow direction imaging while the stepwise pattern was used for each slow axis scan. The decorrelation differences between the forward and the backward inter A-line OCTA were calculated for the horizontal and the vertical fast axis scans, and the ratio of the horizontal and the vertical decorrelation differences was utilized to show the 2D transverse flow direction information.Results: OCTA flow direction imaging was verified using flow phantoms with various flow orientations and speeds, and we identified the flow speed range relative to the scan speed for reliable flow direction measurement. We demonstrated the visualization of 2D transverse blood flow orientations in mouse brain vascular networks in vivo.Conclusions: The proposed OCTA imaging technique that provides information of 2D transverse flow direction can be utilized in various clinical applications and preclinical studies.
Highlights
The proposed optical coherence tomography angiography (OCTA) imaging technique that provides information of 2D transverse flow direction can be utilized in various clinical applications and preclinical studies
Assessment of vessel patency and blood flow direction is critical in various medical situations, including diagnosis and treatment monitoring of ischemic diseases[1,2,3,4,5,6,7,8] and image-guided vascular surgeries.[9,10,11,12,13,14,15,16,17,18,19,20,21]
We demonstrate an OCTA imaging technique for the visualization of twodimensional (2D) transverse blood flow direction information
Summary
Assessment of vessel patency and blood flow direction is critical in various medical situations, including diagnosis and treatment monitoring of ischemic diseases[1,2,3,4,5,6,7,8] and image-guided vascular surgeries.[9,10,11,12,13,14,15,16,17,18,19,20,21] Ischemic diseases are typically characterized by the disruption of the blood flow, such as changes in blood flow speed and blood flow direction.[11]. Downloaded From: https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics on 02 Nov 2021 Terms of Use: https://www.spiedigitallibrary.org/terms-of-use. Shin and Oh: Visualization of two-dimensional transverse blood flow direction using optical coherence. Imaging the blood flow direction during the surgeries that confirms the intended changes of the paths and directions of the blood flow while avoiding any unintended alteration in vessel patency and blood flow direction is highly desirable for monitoring of the immediate effects of the surgery and for quality control of the vascular intervention.[5,9,10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
